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Table 1 Maximum likelihood analysis of positive selection in DNA-encoding proteins linked to water metabolism and skin structure

From: Natural selection in bats with historical exposure to white-nose syndrome

Gene Protein n n M0-M3 M1-M2 M7-M8
   sp. ind. LRT p ω (prop.) LRT p ω (prop.) LRT p
acad10 ACAD10 4 4 19.6 0..495 1.01 (0%) 0.0 1.000 1.36 (13.3%) 1.4 0.877
acp5 TRAP 9 26 191.5 0.001 6.16 (2.0%) 34.4 0.001 6.05 (2.0%) 38.1 0.001
anxa1 ANXA1 9 16 157.4 0.001 8.57 (15.3%) 57.2 0.001 8.03 (15.5%) 59.1 0.001
aqp3 AQP3 8 28 69.7 0.001 9.22 (1.1%) 14.8 0.004 9.19 (1.1%) 17.1 0.001
aqp4 AQP4 3 3 1.3 1.000 1.00 (3.0%) 0.0 1.000 14.87 (2.5%) 0.6 1.000
aqp7 AQP7 3 3 0.1 1.000 1.00 (5.1%) 0.0 1.000 1.00 (0%) 0.0 1.000
aqp9 AQP9 4 4 12.2 0.028 3.19 (15.5%) 4.3 0.292 3.19 (15.5%) 4.6 0.226
bcam BCAM/Lu 6 8 73.5 0.004 5.81 (5.2%) 10.5 0.025 5.32 (5.8%) 11.1 0.018
ctnnb1 CTNNB1 4 4 0.0 1.000 1.00 (0%) 0.0 1.000 1.00 (0%) 0.0 1.000
fads1 FADS1 3 3 18.0 0.03 13.40 (1.5%) 7.0 0.085 13.46 (1.6%) 7.2 0.081
fgf10 FGF10 5 5 7.7 0.155 1.00 (1.7%) 0.0 1.000 1.00 (1.8%) 0.1 1.000
guca2b GUCA2B 7 12 29.1 0.001 3.53 (5.1%) 3.6 0.345 3.23 (6.3%) 5.4 0.172
has2 HAS2 4 4 0.0 1.000 1.00 (0%) 0.0 1.000 1.01 (0%) 0.0 1.000
hyal2 HYAL2 5 5 17.8 0.003 1.00 (2.9%) 0.0 1.000 1.00 (2.9%) 0.0 1.000
hyal3 HYAL3 4 4 0.4 1.000 1.00 (8.2%) 0.0 1.000 1.01 (0%) 0.0 1.000
krt8 KRT8 4 4 0.0 1.000 1.00 (0%) 0.0 1.000 1.00 (0%) 0.0 1.000
lrp4 LRP4 4 4 14.1 0.015 52.96 (1.11%) 9.3 0.035 52.95 (1.11%) 10.1 0.021
psen2 PSEN2 3 3 12.98 0.001 11.39 (1.1%) 4.1 0.351 10.95 (1.2%) 3.9 0.226
ptch2 PTCH2 4 4 67.2 0.001 10.75 (0.4%) 9.110 0.035 10.45 (1.2%) 10.7 0.018
pxn PXN 4 4 6.6 0.225 1.00 (0%) 0.000 1.000 1.00 (0%) 0.0 1.000
sncg SNCG 3 3 13.2 0.020 84.38 (1.1%) 11.506 0.018 85.32 (1.1%) 11.8 0.016
tgm1 TGM1 5 5 6.7 0.620 1.00 (4.8%) 0.000 1.000 1.00 (0%) 0.0 1.000
tnfsf13 TNFSF13/APRIL 4 4 12.1 0.028 14.26 (0.6%) 3.286 0.370 8.6 (1.1%) 3.1 0.404
  1. The table shows ω values indicating the ratio of non-synonymous to synonymous substitution rates. n = sample size; sp. - species; ind. - individuals; LRT likelihood ratio test statistic, given as Δ2lnL in the nested models compared (M0-M3, M1-M2 and M7-M8); prop. - proportion of sites with ω > 1; and p-values (adjusted for multiple testing with FDR; significant at α = 0.05) for the corresponding tests. Tests indicating signals of natural selection are in bold